Diabetes Medicine Linked to "Flesh-Eating" Genital Infection

If you have type 2 diabetes and your genitals are infected, that might not be a coincidence.

A new diabetes medicine has been linked to a string of incidents involving "flesh-eating" genital infections.

MedicalXpress.com reports:

If this happens, new research suggests you need to see your doctor immediately, because you may be suffering from Fournier gangrene. Also known as a "flesh-eating" disease, this infection attacks your genital or anal region and can quickly kill tissue as it spreads rapidly.
Unfortunately, it has become a rare but still possible safety concern for people taking diabetes medications known as SGLT2 inhibitors, according to U.S. Food and Drug Administration scientists.
SGLT2 inhibitors are a newer class of diabetes medications, introduced in 2013. Drugs in this class include canagliflozin (Invokana), dapagliflozin (Farxiga) and empagliflozin (Jardiance).
Fournier gangrene occurred in 55 people taking these drugs between March 2013 and January 2019. For comparison, the researchers looked for cases of Fournier gangrene in people taking other diabetes medications from 1984 to 2019. They found only 19 such cases.
Still, the risk for Fournier gangrene remains very low, the researchers stressed.
"In 2017, an estimated 1.7 million patients received a dispensed prescription for an SGLT2 inhibitor," said study author Dr. Susan Bersoff-Matcha, a medical officer in the FDA's Center for Drug Evaluation and Research. So, "Fournier gangrene is a rare event," she said. "While our study shows an association between treatment with SGLT2 inhibitors and Fournier gangrene, we don't know exactly what the risk is, or if Fournier gangrene can be predicted."
Broad-spectrum antibiotics and surgery to remove the dead tissue are treatment options, the researchers said.
SGLT2 inhibitors work in the kidneys, allowing excess blood sugar to be removed in the urine, they said.

Billy Ed is having a rough morning.

A participant holds carrots and potatoes as a symbol of a penis and testicles, at the tenth annual World Testicle Cooking Championship in the Serbian village of Lunjevica, 110 kilometres south of capital Belgrade, on August 31, 2013. A delicacy for medieval monarchs, then food for the poorest, animal testicles, spiced with a pinch of humour, are back on the menu, at least at a Serbian food festival. Every year the village of Lunjevica hosts the World Testicle Cooking Championship where dishes of various animal testicles are prepared. AFP PHOTO / ANDREJ ISAKOVIC (Photo credit should read ANDREJ ISAKOVIC/AFP/Getty Images)

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